Keywords : leptin

A Study of Adiponectin/Leptin Ratio in Adult Males with Metabolic Syndrome

Iraqi Postgraduate Medical Journal, 2018, Volume 17, Issue 4, Pages 355-359

Metabolic syndrome is a disorder of energy utilization and storage. It is a multi-component disease
brought on by a combination of life style and environmental factors, with some populations
exhibiting a genetic predisposition and type 2 diabetes. It is marked by abdominal obesity, elevated
levels of triglyceride, low levels of HDL (good) cholesterol, high blood pressure and high blood
sugar levels. Metabolic syndrome is a significant risk factor for the development of both type 2
diabetes and heart disease, also associated with fatty liver, and polycystic ovary syndrome.
Recently two adipocytokines secreted from visceral adipose tissue leptin and adiponectin, have
been recognized as key regulators of various metabolic disorder.
The objective of this study was to use the adiponectin to leptin ratio as a parameter and a lab index
to predict metabolic syndrome across adult males.
A total of 82 adult males with mean age of (38.47 + 9.27) were included in the study. Fifty eight
(58) adult males were the metabolic syndrome group depending on the presence of any 3 out of 5
of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria
which include the following: (central obesity ≥ 102cm, triglyceride ≥150 mg/dl, HDL-Cholesterol
˂40 mg/dl, blood pressure ≥ 130/85 mmHg and fasting serum glucose ≥100 mg/dl) as compared to
twenty four (24) healthy adult males as the control group.
The findings showed that adiponectin/ Leptin ratio is significantly lower in metabolic syndrome
adult males as compared to healthy adult males.
In conclusion data indicate that adiponectin/leptin ratio is a plausible index for detecting the
presence of metabolic syndrome in adult males.

Serum leptin Levels and Their Correlation with Thyroid Hormones in Women with Hyperemesis Gravidarum

Miami Abdul Hassan Ali

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 1, Pages 33-38

Leptin is a protein that regulates energy expenditure and food intake. It is found that maternal leptin
level increases progressively during gestation. However, in other hypothesis, rapid increase in
maternal leptin concentration disproportional to gestational week is a marker for hyperemesis
To assess the maternal serum leptin , the adjusted leptin levels in first trimester women with
hyperemesis gravidarum and with normal pregnancy and to find the correlation between leptin level
and thyroid hormones in the two groups.
A case-control study conducted in AL- Yarmouk teaching hospital /department of obstetrics and
gynaecology for one year from March 2009 to March 2010.
A hundred pregnant women were enrolled in this study. Fifty women with hyperemesis gravidarum
and fifty women without hyperemesis gravidarum as a control group were included in the study.The
two groups were compared for age, parity, body mass index. Fasting serum thyroid stimulating
hormone ,free thyronine hormone, free thyroxine hormone and leptin levels were measured . The
adjusted leptin level (ALL ) : maternal serum leptin level / gestational week , was calculated in each
Body mass index was found significantly lower in the hyperemesis gravidarum group than in the
control group(p = 0.018) .The mean leptin level in the hyperemsis gravidarum group was14.78+4.46
ng /ml which was significantly higher (p = 0.035) than the mean leptin level in the control group
which was12.51+4.08 ng/ml.The mean adjusted leptin level in the hyperemsis gravidarum group was
1.86+0.23 which was significantly higher (p<0.001) than the mean adjusted leptin level in the control
group which was1.38+0.20 . Serum thyroid stimulating hormone was significantly lower (p = 0.001)
and free thyronine hormone , free thyroxin hormone levels were significantly higher (p <0.001,
<0.001 respectively) in the hyperemesis gravidarum group than in the control group.
Maternal serum leptin level was significantly higher in the HG group. ALL was also significantly
higher in the HG group and there was no significant correlation between leptin level and thyroid

The Association Between Leptin with Lipid Profile and Troponin in Acute Myocardial Infarction Patients

lmmmA Esmaeel Ibrahim; Hadef Dhafer EL-Yassin; Hamid Kareem Sachit AL-Janabi

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 3, Pages 332-338

Fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat. Adipose tissue also serves as an important endocrine organ by producing hormones such as leptin, resistin, and the cytokine. Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Acute Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some heart cells to die.
To investigate the levels of leptin and its effect on lipid profile level in Acute Myocardial Infarction.
The study included 50 patients with Acute Myocardial Infarction and forty healthy subject as control group. leptin and lipid profile levels were measured.
The levels of leptin were significantly elevated in female patients group with(p=0.002), in male patients group(p=0.018) and in total patients group (p=0.001), cholesterol and LDL-C were significantly elevated with (p<0.001), while HDL-C was significantly lower with (p<0.001), there was positive correlation between leptin with , cholesterol LDL-C, triglyceride and VLDL, and there was negative correlation between leptin with HDL in acute myocardial infarction patients.
Leptin negatively correlated with HDL and positively correlated with triglyceride and LDL this relation make this hormone act as atherosclerotic factor.

Leptin Effect in the Development of Obesity –Related Hypertension in Postmenopausal Women

Waleed Kh. Hussein

Iraqi Postgraduate Medical Journal, 2010, Volume 9, Issue 2, Pages 155-157

Obesity in humans causes hypertension, myocardial hypertrophy and coronary atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related to sympathetic overactivity. Leptin is an adipocyte-derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow. One of the major mechanisms leading to the development of obesity-induced hypertension appears to be leptin-mediated sympatho-activation.
This study is done to evaluate the contribution of leptin in the development of obesity related hypertension in post menopausal women.
A total number of 64 subjects (post menopausal women) included in the study were divided into obese hypertensive group (n= 38 )and non obese non hypertensive group (n=26) , age(57+4.5year) and (56+2.7year) respectively(mean+SD).
Obese hypertensive group defined as (BMI ≥ 30 kg/m2 and blood pressure ≥ 140/90 mmHg with or without history of taking anti hypertensive medications)and Non-obese non hypertensive group defined as (BMI < 30 kg/m2- blood pressure < 140/90 mmHg).In the present study leptin had been measured.
Leptin level is higher in obese hypertensive group than in non obese non hypertensive group and it was 29.2+4 and 15.2+2.1(mean+SD) respectively and this difference is statistically significant with p value < 0.001.
leptin may play a role in the development of obesity- related hypertension and may be an independent predictor of hypertension

Influence of Primary Hypothyroidism on Serum Leptin Level

Aras A. Abdullah; Abdul Hussein A. Farage; Maryam S. Mohammad

Iraqi Postgraduate Medical Journal, 2010, Volume 9, Issue 2, Pages 120-124

ABSTRACT: BACKGROUND: Leptin is the protein product of the ob gene, secreted by adipocytes. It has been suggested that it may plays an important role in regulating appetite and energy expenditure, but beside that, little is known about the physiological actions of leptin in humans. OBJECTIVE: To evaluate a possible influence of primary hypothyroidism on serum leptin levels. METHODS: Fifty-six newly diagnosed patients with primary hypothyroidism (40 females and 16 males) and 32 normal controls matched for age, ethnic status and body mass index (BMI) were studied. Body mass index (BMI; kg/m2), thyroid function(using enzyme-linked immunoflourescent assay) and serum levels of leptin, thyroid autoantibodies (measured by enzyme-linked immunosorbant assay) and lipid profile(measured by enzymatic colourimeteric assays) were assessed in all studied subjects. RESULTS: No significant difference in serum leptin levels was recorded between hypothyroid patients and controls (16.3±14.9; 14.8 ± 12.9, P> 0.05), but women in each group had significant higher leptin concentrations than men (patients: 19.6 ±16.3 vs. 8.3 ±5.0; controls: 19.0 ±14.4 vs. 7.7 ±4.1; P< 0.05). Serum levels of cholesterol (p<0.002), LDL-cholesterol (p<0.004) and atherogenic ratio (p<0.03) were generally higher in patients than controls. The serum leptin concentration correlated positively with BMI within both patients (r=0.32; p<0.016) and controls (r=0.28; p<0.024). However, no association was demonstrated between values of serum T3, T4, TSH, triglyceride, HDL-cholesterol and thyroid auto antibodies. CONCLUSION: Circulating thyroid hormones do not appear to play any significant effect on leptin levels in patients with primary hypothyroidism.

The Effect of Obesity on Serum Leptin and Lipid Profile

Kismat Mohammad Turki

Iraqi Postgraduate Medical Journal, 2009, Volume 8, Issue 1, Pages 27-32

Obesity has become a leading health concern; this condition is a chronic, complex, multifactorial disease in which a person's weight is ≥ 20% of the ideal weight for a given height.
To measure serum leptin level and lipid profiles levels in Iraqi obese individuals comparing the results with matching non obese subjects.
The study was carried on 30 individuals divided into two groups:
1. Obese subjects group (n=20).
2. Non-obese subjects group (n=10).
For all subjects studied measurements of fasting serum leptin and lipid profile have been done.
Our study showed that mean serum leptin level was significantly higher in obese than non-obese individuals (P<0.001). In addition serum leptin correlates positively and strongly with body mass index (BMI) ( r=0.765,P<0.01). Serum leptin also correlates positively with both triglyceride (TC)(r =0.394, P<0.05) and low density lipoprotein (LDL) (r=0.366,P<0.05) but correlates negatively with high density lipoprotein (HDL)(r=-0.408,P<0.05).
circulating leptin levels appear to be one of the best biological markers of obesity and hyperleptinemia is closely associated with several risk factors related to obesity syndrome.