Keywords : coronary artery disease

The Study of Association Between Toxoplasma gondii Infection with Ischemic Heart Diseases

Tariq.Q.Tallab; Jabbar R. Al-Autabbi; Dhiaa.k.Al-Umer

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 4, Pages 557-561

Coronary artery disease (CAD) is the main cause of mortality in industrial and developing countries. New risk factors including infections are under investigation as potential factors. One of these infectious agents is Toxoplasma gondii, few data have been published on the association of atherosclerosis (the usual cause of ischemic heart disease) and Toxoplasma gondii infection. The OBJECTIVE:
Was to investigate potential role of T.gondii infection as a risk factor for coronary atherosclerosis in ischemic heart disease patients and the correlation between T.gondii with other cardiovascular risk factors
This study was conducted on (58) patients with Ischemic Heart Diseases attended cardiac care unite in Al-Hussein teaching hospital in Nasseriya city, southern Iraq and 32 healthy controls ,all are free from clinically evident disease were attending the blood bank in Nasseriya city between November 2010 to the end of August 2011. the sera of the patients and control groups were tested for T.gondii antibodies using Enzyme-Linked Immunosorbent Assay (ELISA) technique. The obtained data was analyzed and the results were tabulated.
22(37.9 %) in the case group and 11(34.4 %) in the control group were seropositive for T.gondii antibodies, odds ratio (OR) 1.167 . P= 0.915 . And there were no association between risk factors and Toxoplasma gondii infection, (Table 2, 5). ( Figure 1).
This study shows that there is no association between Toxoplasma gondii infection and ischemic heart disease

Blood Glucose Concentration and Ischemic Heart Failure

Basil Oied Mohammed Saleh

Iraqi Postgraduate Medical Journal, 2008, Volume 7, Issue 3, Pages 241-244

Schemic heart failure (IHF) is the most common cause of congestive heart failure. Several studies have revealed that hyperglycemia is an independent risk factor for the progression of IHF in the general population.
Is to evaluate the relationship between fasting blood glucose concentration and the development of IHF in patients with CAD.
This study included 28 patients with IHF, 22 patients with coronary artery disease (CAD) without HF and 22 healthy controls. Fasting plasma glucose, total cholesterol, and low density lipoprotein-cholesterol( LDL- C) were measured in these two groups of patients and controls.
The present study revealed that the mean (± SEM) value of fasting plasma glucose in patients with IHF (127 ± 7.64 mg/dl) was significantly higher than that obtained from CAD patients without HF (93.6 ± 3.96 mg/dl, P<0.0001) as well as from healthy controls (80.8 ± 2.52 mg/dl, P<0.0001). The mean values (± SEM) of serum total cholesterol and LDL-Cholesterol did not differ significantly among the three groups of the present study.
This study showed that serum glucose level may play an important role (partially) in the development and progression of IHF in patients with CAD and normal cardiac contractile function.