Keywords : reactive protein


Pleural Fluid C-Reactive Protein in the Differential Diagnosis of Infectious and Malignant Pleural Effusion at Baghdad Teaching Hospital (Single Center Study).

Iraqi Postgraduate Medical Journal, 2018, Volume 17, Issue 1, Pages 22-29

ABSTRACT:
BACKGROUND:
C-reactive protein (CRP) is an acute phase reactant produced primarily by hepatocytes; its production is stimulated by systemic inflammation of either infectious or noninfectious origin. The cytokines that are released during the inflammation are the main stimulants of the acute phase reactants. Interleukin-6 is the main stimulant cytokine of the synthesis of most acute-phase reactants.
OBJECTIVE:
To differentiate between infectious and malignant pleural effusions by measuring pleural fluid CRP titer.
MATERIALS AND METHODS:
This was a hospital-based cross-sectional study at Baghdad teaching hospital medical wards conducted from the 1st of November 2014 up to the 31th of august 2015.
Fifty patients with pleural effusion proved by the history, examination,
Chest imaging and pleural tapping included in this study, all proved to have
An exudative pleural effusion by the light criteria.
RESULTS:
Showing statistically significant differences in CRP titer between:-
1-Parapneumonic pleural effusion (PPE) and malignant pleural effusion (MPE)
2-TB pleural effusion (TBPE) and malignant pleural effusion (MPE).
CONCLUSION:
Pleural fluid C-reactive protein titer can be used as an aid in the differentiation between some infectious causes of pleural effusion and malignant pleural effusion as there is a statistically significant difference between the Pleural fluid C-reactive protein titer of the infectious pleural effusion and the malignant pleural effusion.
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Pleural Fluid C-reactive Protein in the Differential Diagnosis of Infectious and Malignant Pleural Effusion at Baghdad Teaching Hospital (Single Center Study).

Kareem Abass Kareem; Mohammed Waheeb Salman AL.Obaidy; Kassim .M. Sultan

Iraqi Postgraduate Medical Journal, 2017, Volume 16, Issue 3, Pages 304-310

ABSTRACT:
BACKGROUND:
C-reactive protein (CRP) is an acute phase reactant produced primarily by hepatocytes; its production is stimulated by systemic inflammation of either infectious or noninfectious origin. The cytokines that are released during the inflammation are the main stimulants of the acute phase reactants. Interleukin-6 is the main stimulant cytokine of the synthesis of most acute-phase reactants.
OBJECTIVE:
To differentiate between infectious and malignant pleural effusions by measuring pleural fluid CRP titer.
MATERIALS AND METHODS:
This was a hospital-based cross-sectional study at Baghdad teaching hospital medical wards conducted from the 1st of November 2014 up to the 31th of august 2015.
Fifty patients with pleural effusion proved by the history, examination,
Chest imaging and pleural tapping included in this study, all proved to have
An exudative pleural effusion by the light criteria.
RESULTS:
Showing statistically significant differences in CRP titer between:-
1-Parapneumonic pleural effusion (PPE) and malignant pleural effusion (MPE)
2-TB pleural effusion (TBPE) and malignant pleural effusion (MPE).
CONCLUSION:
Pleural fluid C-reactive protein titer can be used as an aid in the differentiation between some infectious causes of pleural effusion and malignant pleural effusion as there is a statistically significant difference between the Pleural fluid C-reactive protein titer of the infectious pleural effusion and the malignant pleural effusion.

Evaluation of Certain Acute Phase Reactants in Patients with Acute Myocardial Infarction

Noaman Abdullateef Abdulrazzaq; Abdulbasit Insief Jassim; Ali Ibrahim Kadhum

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 2, Pages 176-180

ABSTRACT:
BACKGROUND :
Acute myocardial infarction ( AMI ) is an important clinical condition which is associated with a significant inflammatory changes that result in acute-phase responses. Significantly elevated concentrations of cytokines and other acute phase reactants are the major events that accompanied such condition. Our aim was to evaluate certain acute phase reactants : Interleukin-6 ( IL-6 ) , C-Reactive Protein ( CRP ) and plasma fibrinogen in patients with AMI.
OBJECTIVE:
This study was focused on the evaluation of certain acute phase reactants : Interleukin-6 ( IL-6 ) , C-Reactive Protein ( CRP ) and plasma fibrinogen in patients with AMI.
PATIENTS AND METHODS:
Thirty patients from Baghdad city with AMI were included between July 2011 and January 2012 : 21 males and 9 females, their ages range between 40 – 73 years. Thirty healthy subjects ( 16 males, 14 females ), age matched with patients as a comparative group were included. Both groups were investigated for IL-6 , CRP , and plasma fibrinogen levels.
RESULTS :
IL-6 concentrations were found to be significantly higher with ( P value : 0.0001 ) –table 1- in patients with AMI) than in control subjects. CRP concentrations were also found to be significantly higher with ( P value : 0.0001 ) in patients with AMI than in control subjects. plasma fibrinogen level was significantly higher with ( P value : 0.0001 ) in patients with AMI than in control subjects.
CONCLUSION :
The study revealed a significant elevation in IL-6 , CRP concentrations and plasma fibrinogen level in patients with AMI.

Evaluationof Highly Sensitive C-Reactive Protein in Female Patients with Nodal Osteoarthritis

Ammar W. Obeid; Munaf S. Daoud; Mohammed H. Alosami

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 4, Pages 479-484

ABSTRACT:
BACKGROUND:
Nodal Osteoarthritis is a subset of OA characterized by polyarticularinterphalangeal and thumb base OA ,Heberden’sand Bouchard’s nodes formation.C-reactive protein (CRP) is one of the first acute phase response proteins to be elevated in an inflammatory processes.
OBJECTIVE:
The aim of this study is to investigate whether the inflammatory processes have roles in the development of nodal osteoarthritis (NOA) in Iraqi femalepatients using serum highly sensitive C-reactive protein as aninflammatory marker.
SUBJECTS AND METHODS:
The study included eighty four females, divided into two main groups,sixty were patients with (NOA), and twenty-four represented the control group. Other subdivisions were applied according to body mass index and menopause status. Measurement of serum (hsCRP), wasapplied to all subjects included in this study, by ELISA sandwich method.
RESULTS:
Serum highly sensitive C-reactive protein (hsCRP) level was significantly higher (18.08±8.15) (P value < 0.05) in patients with NOA in comparison to control group (2.23±1.73) .
CONCLUSION:
Highly significant elevated level of serum (hsCRP) observed in the NOA patients compared to control suggest that the inflammatory processes have roles in the development of NOA.

Diagnostic Value of C - Reactive Protein and Other Hematological Parameters in Neonatal Sepsis

Hafadh Jaleel Hussein; Yusra Fayyadh Alwan

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 3, Pages 370-375

ABSTRACT:
BACKGROUND:
There have been many attempts to develop screening tests or scoring systems that can identify infected infants at the time of initial assessment, sparing others from invasive diagnostic procedures, intravenous antibiotics therapy, mother-infant separation and parental anxiety.
OBJECTIVE:
Is to analyze hematological parameters and C - reactive protein so as to evaluate their diagnostic value in neonatal sepsis.
PATIENTS AND METHODS:
A cross-sectional study was performed in the neonatal care unit (N.C.U) at the Central Teaching Hospital for Pediatrics and Al-Habibiya Maternity and Children Teaching Hospital during a period from the first of June 2005 to the first of January2006
One hundred neonates having clinical features of sepsis and 100 normal asymptomatic neonates were evaluated with a set of investigations including C-reactive protein(CRP), White Blood cells
Count(WBC), Absolute Neutrophil count (ANC), Platelets count (thrombocytopenia), Immature to Total neutrophil ratio (I/T ratio) and Erythrocyte Sedimentation Rate (ESR) to diagnose neonatal sepsis.
RESULTS:
C-reactive protein (CRP) was positive in (82.4%) of group-A and (81.8%) of group-B and had a specificity of 93.0%. ANC was the second most sensitive test having sensitivity of 61.8% for group-A and 48.5% for group-B and specificity of 86.0%.
The sensitivities of platelets count (thrombocytopenia), WBC, I/T ratio and ESR for group-A were: 55.9%, 29.4%, 17.6% and 26.5% respectively, with specificities of 91.0%,
89.0%, 92.0% and 81.0% respectively. While group-B had sensitivities of 42.0%, 33.3%,
15.2% and 22.7% respectively with specificities of 91.0%, 89.0%, 92.0% and 81.0%respective ly.
CONCLUSION:
The implementation of CRP and other hematological parameters (ANC, Platelets count and WBCs) are useful in early detection of neonatal sepsis and diagnosis of neonatal sepsis in those who have false negative blood cultures

Evaluation of the Complement (C3) in Patients with Acute Coronary Syndrome

Basil Najeeb; Ali Hiad; Ebtsam A. Saleh; mnther A Tlair Haider; EMAD J. M MT

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 1, Pages 40-45

ABSTRACT: BACKGROUND: To evaluate complement activation (C3) levels in all forms of acute coronary syndrome (ACS) and to find whether there is any significant changes in C3 concentration at the 1st and 4th day after admission and its relation to clinical outcome. OBJECTIVE: Comparing the degree of complement activation (C3 level) between ACS and stable pectoris.To know whether there is any significant difference between the level C3 at first and fourth day. Any correlation between CRP and C3 in patients with ACS. PATIENT AND METHODS: 129 subjects (94 male and 35 female) age range (41-72 years, mean age 57 ± 10.6) were admitted in this study over the period of Feb 2009-Jan 2010 categorized into three groups; 76 patients with acute coronary syndrome (group A), 25 patients with stable angina (group B) and 28 healthy control (group C). Full clinical, biochemical, electrocardiographic and echocardiographic studies liveredone. All patients were followed to the fourth day of admission, Blood samples from peripheral veins were collected centrifuged and Serum C3 levels were measured using immunokit based on single immunodiffusion. RESULTS: The sample of patients was (129) subjects (94 male 72.9%) and (35 female 27.1%). Troponin (I) was positive in 35.7% and negative in 64.3% of the study sample (p. value 0.0005). C-reactive protein (CRP) was significantly correlated with different groups (p. value 0.0004).the same with diabetes mellitus (p. value 0.0003) but not in hypertensive and smokers (p. value 0.486 and 0. 368 respectively).C3levels was significant in correlation to clinical status in both STEMI and NSYEMI 1st and 4th day. Correlation between C3 and C-reactive protein level was insignificant with different groups. CONCLUSION: C3 levels was significantly elevated in correlation between ACS compared to patient with stable angina and healthy control subjects. Also C3 level was significant at the fourth day of admission in patients with NSTEMI in correlation to its level at the first day. However no significance associations between C3 levels and CRP in different studied groups

Diagnostic Value of C Reactive Protein Measurement in Patients with Acute Appendicitis

Maitham H. Kenber

Iraqi Postgraduate Medical Journal, 2007, Volume 6, Issue 4, Pages 347-351

ABSTRACT:
OBJECTIVES :
To evaluate the role of crude measurement of C-reactive protein in the diagnosis of acute appendicitis.
BACKGROUND:
Appendicectomy for suspected acute appendicitis is a common procedure. The rate of normal appendices unnecessarily removed remain high(15%-30%) ; despite several techniques and investigations used to improve the diagnostic accuracy . Many studies investigated the role of raised C-reactive protein (CRP ) in improving the diagnosis of acute appendicitis, but with conflicting results.
PATIENTS AND METHODS :
This is a randomized prospective study from February to July 2006 . A total of 100patients were included in this study that presented to our hospital with acute right iliac fossa pain and later on operated and had appendicectomy .Blood for the measurement of serum C-reactive protein(CRP) was collected preoperatively from all the patients. The patients divided in to two groups ,those who are positive appendicitis proved by operative finding and histopathological examination and those with negative appendicitis proved by histopathological examination.
RESULT:
A total of 100 patients were included in this study, and out of these 16 (16%) had normal appendix giving an over all negative appendicectomy rate of 16% out of these 5 were males and 11 were females ,the age range was (6-47 years) with a median age of ( 25.92) years . Among the 84 who had appendicitis, 64 patients had obstructive type of appendicitis which were noticed during the operation ,and CRP was positive in all patients, but only 9 of them were with CRP negative . 4 perforated appendicitis were found in which all of them were CRP positive, and 16 patients with catarrhal appendicitis were diagnosed by histopathological examination and only 3 patients out of those had negative CRP while the remainder were positive.
CONCLUSION:
The positivity of CRP was related to the severity of inflammation; but it is more reliable to depend on negative results to postpone the operation and observe the patient .Thus unnecessary removal of normal appendices may be reduced.