Keywords : Albumin


A Study of Serum Protein Electrophoresis in Patients with Multiple Myeloma

Hind Shakir Ahmed

Iraqi Postgraduate Medical Journal, 2013, Volume 12, Issue 4, Pages 494-498

ABSTRACT:
BACKGROUND:
Multiple myeloma (MM) is caused by the malignant proliferation of plasma cells through the bone marrow. The clinical features are due to disordered immunoglobulin synthesis and/or secretion from the cell. The amount of protein in the vascular compartment depends on the balance between the rate of synthesis and catabolism or loss. Electrophoresis is a technique that separates compounds such as proteins according to their different electrical charge. In this way, five main groups of proteins namely albumin and the α1, α2, β, γ-globulins, may be distinguished after protein staining and may be visually compared with those in a normal control serum.
OBJECTIVE:
To evaluate total serum protein, serum albumin, serum globulin, and serum protein electrophoresis in Iraqi MM patients.
PATIENTS AND METHODS:
This study was conducted during the period from August 2012 until the end of November 2012. The patients were admitted to Medical City Hospital and all the measurements were performed in the Medical Teaching Laboratories in Baghdad. Total serum protein was measured by colorimetric Biuret method, while serum albumin was measured by bromocresol green method, serum globulin, and serum protein electrophoresis were measured in 25 patients with MM; their age range was (50-70) years and compared with 25 healthy controls.
RESULTS:
Total serum protein and serum globulin were significantly increased (86.76±17.05 g/l and 55.36±20.54 g/l respectively) in patients with MM, as compared with their controls, (P=0.0001). While a significant decreased was found in serum albumin (29.6±8.77 g/l) and albumin to globulin ratio (0.64±0.36 g/l) for patients with MM as compared with their controls, (P=0.0001).
CONCLUSION:
Abnormal concentrations of total serum protein, serum albumin, serum globulin, and M-band are associated with MM

Prognostic Significance of Serum Albumin Levels in Patients with Systolic Heart Failure

Muataz Fawzi Hussein

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 3, Pages 411-417

ABSTRACT:
BACKGROUND:
Hypoalbuminemia is considered as poor prognostic factor in patients with certain chronic diseases, such as cancer and end-stage renal failure. Low serum albumin is common in patients with heart failure; nevertheless, the relationship between serum albumin and heart failure prognosis has not been well verified.
OBJECTIVE:
To elucidate the effect of serum albumin level on prognosis of patients with systolic heart failure.
METHODS:
This study included 250 patients with systolic heart failure who were admitted to Baghdad teaching hospital between February 2008 and April 2010. Patients were divided into groups based on presence of hypoalbuminemia (≤3.4 g/dL).
RESULTS:
The mean age of patients was 55 ± 14 years and the mean left ventricular ejection fraction [LVEF] was 28 ± 11 %). The mean serum albumin was 3.9 ± 0.7 g/dL; 27.2 % of patients had hypoalbuminemia. Patients with and without low serum albumin levels were similar in age, cause of heart failure, and ejection fraction. Patients with hypoalbuminemia had higher New York Heart Association (NYHA) class, higher serum urea, creatinine and C-reactive protein levels but lower levels of sodium, hemoglobin, and cholesterol. In patients with body mass index (BMI) < 25 kg/m2, 26% had hypoalbuminemia compared to 20% in those with BMI ≥25 kg/m2 (P ≤ 0.01). One-year survival was 64.71% in patients with and 85.72% in those without hypoalbuminemia (P < 0.001). Risk-adjusted hazard ratio for 1-year mortality was 1.9 (1.5-2.4).
CONCLUSION:
Hypoalbuminemia is common in patients with heart failure and is independently associated with increased mortality.

Correlation of Angiographic Findings and Clinical Presentations in Unstable Angina

Ali Abdulamir Mohammad AL.Mossawi; Kasim Abbas Ismail; Azher Sabih Zubaidy; Adil Siwan Aqabi; Majid Hameed AL Maini; Jawad K. Mnuti; Fadhil A. AL- Abbudi; Amira H. Shubbar; Layth Rafea Taqa; Sawsan Sati; Abbas; Najat Abul; Razak; Noor Mustafa; Razeqa Abd Ali; Nassir Enssief Mohsun; Raji H AL-Hadithi; Suhaila Saadallah; Darya Akram Faqe Mahmood; Ari R. Qader; Kurdo A. Mohmmad; Dawood Salman Hameed Alazzawi; s Central Teaching Hospital in Baghdad; a Descreptive Study; Autism Among Children Attending Pediatric Psychiatric Department in Child; Jaafar Muhamed Hassan; AL- Ghabban; Haider Abdul Muhsin; Huda Adnan Habib; Maysaloun Muhammed Abdulla; Selwa Elias Yacoub; Abdulrazak H. Alnakash; Shaema Jafar; Yousef Abdul-Raheem; Alaa Hussein Ali; Montadhar Hameed Nima; Rasha Abbas Azeez; Jassim Mohammad Alkhazraji; Hussein Mahmood Gazi; Mohammed Shafik Tawfeek; Nabeel Ghazi Hashim; Hayder Hadi Lazim; Maysoon Mohammad Najeeb Mohammad Saleem; Arieg Abdul Wahab Mohammad; Majid Syki Jabir; Kareem Al-Tameemi; Malak A. Al-Yawer; Adel Rabea Alsaadawi; Mohammed S. Saeed; Thukaa T. Yahya; Osama E. Hudder; Issraa A. Hussein

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 4, Pages 449-455

ABSTRACT: BACKGROUND: Unstable angina is usually related to acute thrombosis superimposed on a disrupted plaque. The highest; level of Braunwald classification of unstable angina can be used to assess the severity of clinical presentation. However the highest classes have not been directly correlated with thrombotic and complex lesions. OBJECTIVE: The study was done to clarify the correlation between angiographic findings and the most acute and / or severe clinical presentation in unstable angina. PATIENTS AND METHOD: We conducted a prospective study of 110 patients of unstable angina at Ibn-Albitar Center for Cardiac Surgery. All of these patients underwent cardiac catheterization, culprit lesion was identified in 80 patients and in 30 patients there was no an identifiable culprit lesion .Complex lesions including complex morphology, intracoronary thrombus, or total occlusion were also quantitatively analyzed and Thrombolysis in Myocardial Infarction (TIMI) flow grade was assessed. Patients were classified according to Braunwald classification in instable angina .We compared patients with and those with no culprit lesions in regarding Braunwald classification. We sequentially compared the highest Braunwald classes II, C, 3 with classes

Keywords

braunwald classification
---
unstable angina

Intraoperative Albumin Plus Crystalloid Solution Versus Crystalloid Alone in Renal Transplant Surgery

Alaa Hussein Ali

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 4, Pages 526-530

ABSTRACT:
BACKGROUND:
Chronic renal failure is defined as an irreversible deterioration in renal function which classically
develops over a period of months or years. renal transplantation is the treatment of choice for end
stage renal failure and during surgery the maintenance and restoration of intravascular volume are
essential tasks to achieve sufficient organ function in renal transplants.
OBJECTIVE:
To study the comparison between normal saline 0.9% with glucose 5 % and normal saline 0.9% ,
glucose 5 % with albumin in renal transplantation.
METHODS:
The study data from 50 patients 47 patients underwent living donor kidney transplants three were
excluded because they are diabetics .twenty three patients received normal saline 0.9% , glucose
saline 5%,and twenty four received normal saline 0.9 with glucose 5% and albumin 100 milliliter .
RESULT:
There was no statistical difference between the two groups in the primary measurement of outcome
measure in the urine output in the 1st day and the serum creatinine in the 1stand 3rd day .
CONCLUSION:
Although statistically there was no difference in the two groups, it might be its useful to combine a
colloid with a crystalloid in the fluid management regimen to improve microcirculation, oxygen
perfusion and to ovoid large volumes of crystalloid.

Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome

Halla G. AL-Gebouri; Zuhair AL-Mashhadani; Mohammad H. AL-Osami; Kisma M. Turki

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 1, Pages 101-105

ABSTRACT:
BACK GROUND:
Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.
OBJECTIVE:
To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.
PATIENTS AND METHOD;
The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).
RESULTS:
MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.
CONCLUSION:
oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.

Correlation of Angiographic Findings and Clinical Presentations in Unstable Angina

Ali Abdulamir Mohammad AL.Mossawi; Kasim Abbas Ismail; Majid Hameed AL Maini; Adil Siwan Aqabi; Azher Sabih Zubaidy; Jawad K. mnuti; Fadhil A. AL- Abbudi; Amira H. Shubbar; DEFINITION GERD is described as any symptomatic or histopathological alteration resulting from episodes of gastroesophageal reflux; Layth Rafea Taqa; INTRODUCTION; Reflux esophagitis describes the subset of GERD patient with histopathological changes of; Sawsan Sati; Najat Abul; Razak; Noor Mustafa; Razeqa Abd Ali; Suhaila Saadallah; Raji H AL-Hadithi; Darya Akram Faqe Mahmood; Ari R. Qader; Kurdo A. Mohmmad; Dawood Salman Hameed Alazzawi; Entissar Hadi AL- Shimery; Jaafar Muhamed Hassan; AL- Ghabban; Haider Abdul Muhsin; Huda Adnan Habib; Maysaloun Muhammed Abdulla; Selwa Elias Yacoub; Abdulrazak H. Alnakash; Shaema Jafar; Yousef Abdul-Raheem; Alaa Hussein Ali; Montadhar Hameed Nima; Rasha Abbas Azeez; Jassim Mohammad Alkhazraji; Hussein Mahmood Gazi; Mohammed Shafik Tawfeek; Nabeel Ghazi Hashim; Hayder Hadi Lazim; Maysoon Mohammad Najeeb Mohammad Saleem; Arieg Abdul Wahab Mohammad; Majid Syki Jabir; Kareem Al-Tameemi; Malak A. Al-Yawer; Adel Rabea Alsaadawi; ABSTRACT; Issraa A. Hussein; Osama E. Hudder; Thukaa T. Yahya

Iraqi Postgraduate Medical Journal, 2010, Volume 9, Issue 4, Pages 449-455

ABSTRACT:
BACKGROUND:
Unstable angina is usually related to acute thrombosis superimposed on a disrupted plaque. The highest;
level of Braunwald classification of unstable angina can be used to assess the severity of clinical
presentation. However the highest classes have not been directly correlated with thrombotic and complex
lesions.
OBJECTIVE:
The study was done to clarify the correlation between angiographic findings and the most acute and / or
severe clinical presentation in unstable angina.
PATIENTS AND METHOD:
We conducted a prospective study of 110 patients of unstable angina at Ibn-Albitar Center for Cardiac
Surgery. All of these patients underwent cardiac catheterization, culprit lesion was identified in 80
patients and in 30 patients there was no an identifiable culprit lesion .Complex lesions including complex
morphology, intracoronary thrombus, or total occlusion were also quantitatively analyzed and
Thrombolysis in Myocardial Infarction (TIMI) flow grade was assessed. Patients were classified
according to Braunwald classification in instable angina .We compared patients with and those with no
culprit lesions in regarding Braunwald classification. We sequentially compared the highest Braunwald
classes II, C, 3 with classes

Keywords

braunwald classification
---
unstable angina

Intraoperative Albumin Plus Crystalloid Solution Versus Crystalloid Alone in Renal Transplant Surgery

Alaa Hussein Ali

Iraqi Postgraduate Medical Journal, 2010, Volume 9, Issue 4, Pages 526-530

ABSTRACT:
BACKGROUND:
Chronic renal failure is defined as an irreversible deterioration in renal function which classically
develops over a period of months or years. renal transplantation is the treatment of choice for end
stage renal failure and during surgery the maintenance and restoration of intravascular volume are
essential tasks to achieve sufficient organ function in renal transplants.
OBJECTIVE:
To study the comparison between normal saline 0.9% with glucose 5 % and normal saline 0.9% ,
glucose 5 % with albumin in renal transplantation.
METHODS:
The study data from 50 patients 47 patients underwent living donor kidney transplants three were
excluded because they are diabetics .twenty three patients received normal saline 0.9% , glucose
saline 5%,and twenty four received normal saline 0.9 with glucose 5% and albumin 100 milliliter .
RESULT:
There was no statistical difference between the two groups in the primary measurement of outcome
measure in the urine output in the 1st day and the serum creatinine in the 1stand 3rd day .
CONCLUSION:
Although statistically there was no difference in the two groups, it might be its useful to combine a
colloid with a crystalloid in the fluid management regimen to improve microcirculation, oxygen
perfusion and to ovoid large volumes of crystalloid