Keywords : Transitional cell carcinoma


Immunohistochemical Expression of Cyclin D1 in Urothelial Carcinoma of Urinary Bladder

Iraqi Postgraduate Medical Journal, 2019, Volume 18, Issue 2, Pages 161-168

ABSTRACT:
BACKGROUND:
Transitional cell carcinoma is the most common cancer in urinary bladder. Bladder carcinoma is the 5th from the most common ten cancersin Iraq, It is the 2nd in males and the 10th in females according to Iraqi Cancer Registry. It is the 4th most common cancer in inmales, 8thin females in the USA.
OBJECTIVE:
To evaluate the immunohistochemical expression of cyclin D1 in transitional cell carcinoma of urinary bladder and its role in predicting type, grade, stage, progression and prognosis of the tumor.
MATERIALS AND METHODS:
This is retrospective study of 40 bladder biopsy (formalin fixed ,paraffin embedded). Two sections of 5 μmthickness were taken from each block, the first was stained with H&E, the 2nd was stained immunohistochemically for cyclin D1.
RESULTS:
The majority of cases were high grade papillary urothelial carcinoma stage T1 .Nine of cases were score 0 of 4 , six of cases were score 1, three of cases were score 2 ,eleven of cases were score 3,eleven of cases were score 4.
CONCLUSION:
There was no statistical significant correlation between cyclinD1 immunohistochemical expression and tumor stage, grade and type.
KEYWORDS: cyclinD1 expression, Transitional cell carcinoma

Schistosoma – Associated Bladder Cancer: is There a Change in The Trend of Cell Type?

Hassan Abol-Enein Hassan

Iraqi Postgraduate Medical Journal, 2007, Volume 6, Issue 3, Pages 211-214

ABSTRACT:
OBJECTIVE:
To compare the contribution of squamous cell and transitional cell types to the schistosoma – related and schistosoma – unrelated bladder cancer among Egyptian patients and to evaluate any significant association of carcinoma in situ (CIS) and stage T1 – TCC in schistosomiasis.
MATERIALS AND METHODS:
A retrospective study in which the histopathologic records of 196 patients who underwent radical or salvage cystectomy for bladder cancer from August 1994 to December 2000 in Urology and Nephrology Center/ Mansoura University – Egypt, had been carried out.
RESULTS:
The age range of patients was (29 – 75) with a mean of (55.82 ± 8.81) years. Histopathologic examinations of cystectomy specimens showed schistosomiasis in 81(41.32%) patients while in 115 (58.67%) patients; bladder cancer was schistosoma – unrelated. The cell type of cancer in (80) patients with schistosomiasis, was transitional cell carcinoma (TCC) in 40 (50%), squamous cell carcinoma (SCC) in 37 (46.25%), and adenocarcinoma in 3 (3.75%) patients. In schistosoma – unrelated bladder cancer, TCC was reported in 76 (66.08%), SCC in 34 (29.56%), undifferentiated carcinoma in 4 (3.47%) and adenocarcinoma in 1 (0.86%) patients. CIS associated with (stage T1 – TCC) was reported in 2 (15.38 %) out of 13 patients with schitosoma – related bladder cancer, while it was reported in 3 (14.28%) out of 21 patients with schistosoma – unrelated bladder cancer. There was no significant statistical difference between the two groups.
CONCLUSION:
Schistosoma – related bladder cancer is still a problem in countries endemic with schistsomiasis. Although the major histological cell type in such cancer is SCC, there is a trend of increasing frequency of schistosoma – related TCC.