Keywords : muscle invasive bladder cancer

Comparison of Accuracy Between CT Versus MRI in Staging of Muscle Invasive Bladder Carcinoma

Mohammed Noori Al-Musawi; Anas Mohammed Al-obaidi

Iraqi Postgraduate Medical Journal, 2021, Volume 20, Issue 1, Pages 72-78
DOI: 10.52573/ipmj.2021.167829

Transitional cell carcinoma of the bladder is one of the most widely recognized cancers affecting the genitourinary tract  and it is the second most common cancer in Iraqi male population .Cross sectional imaging studies assume a significant role in the staging of this cancer , also the prognosis of  the patients with bladder carcinoma worsens with higher stage and accurate preoperative radiological staging is required to increase cancer free  survival for patients submitted for radical cystectomy.
To compare the accuracy of computed tomography and magnetic resonance imaging for staging of muscle-invasive bladder cancer.
Twenty patients were included in the study hnd undergone staging for their muscle invasive bladder cancer by the use of computed tomography scan and magnetic resonance imaging at least two weeks of their last trans-urethral resection of tumour, the radiological staging was compared to the staging of the histopathological reports of the radical cystectomy of the included patients.
The staging accuracy of the computed tomography was 93.8%, sensitivity 88.8%, specificity 90.2%, while magnetic resonance imaging accuracy of staging was 71.30%, sensitivity 45.8%, specificity 81.70%. Accuracy increased with advancing stage.
It is concluded that computed tomography staging is more accurate than magnetic resonance imaging tumor staging in patients with muscle invasive bladder cancer, with comparable results in lymph node staging.

Effectiveness of Immediate Mitomycin C Instillation in Patients with Low Risk Non-Muscle Invasive Bladder Cancer

Usama Sulaiman Al-Nasiri; Wisam Ali Kareem

Iraqi Postgraduate Medical Journal, 2009, Volume 8, Issue 4, Pages 387-392

We determined if immediate instillation chemotherapy after transurethral resection (TUR) decrease the risk of recurrence andor progression in patient with stage Ta T1 bladder cancer.
This study has been designed to analyze the impact of a single immediate mitomycin C instillation after transurethral resection of bladder cancer on recurrence and progression rates in patients with low risk superficial bladder cancer.
A total of 50 patients with low risk superficial bladder cancer were included in a prospective randomized controlled trial. All patients had a 3 cm. or less single, papillary bladder tumer. The tumor was completely resected before patients were randomized into 2 arms of no further treatment (control group) and a single immediate instillation (usually within 6 hours) of 40 mg. mitomycin c (mitomycin c group). Median follow up was 24 months .The events studied were the recurrence free rate, the recurrence rate/year, and the number of new tumors developing /year.
At 24-month follow-up the recurrence-free rate was significantly increased (84.7% VS 54.2%). Recurrence (15.3% VS 45.8%), and recurrence per year rate (7% VS 20%) and tumor per year rate(11% VS 33%) were significantly decreased in the mitomycin c compared to the control group.
This study confirms the positive effect of a single immediate mitomycin C instillation in patients with low risk superficial bladder cancer. Thus, this approach is an alternative to observation. This study also suggests cell implantation as a mechanism of early recurrence can be controlled with a single immediate mitomycin c instillation.