Keywords : ondansetron

The timing of Ondansetron Administration in Prevention of Postoperative Nausea and Vomiting A comparative Study for Female Patients Undergoing Laparoscopic Cholecystectomy

Sabah Noori Al-Saad

Iraqi Postgraduate Medical Journal, 2013, Volume 12, Issue 3, Pages 449-453

Postoperative nausea and vomiting (PONV) is a common distressing experience in patients following
laparoscopic cholecystectomy.
This study was aimed at comparing the better timing of Ondansetron administration in prevention of
PONV in female patients underwent elective laparoscopic cholecystectomy done under general
Fifty ASA physical status I and II female patients, aged 19 to 45 years, were enrolled in this prospective
study to receive 4mg IV Ondansetron preoperatively (Group A), or 4 mg IV Ondansetron
postoperatively (Group B), 25 patients each. A standardized general anesthetic technique was
employed. Any episode of PONV was assessed at 8 hours postoperative period, every 2 hours, starting
at time zone 0 (at post-anesthesia recovery unit), and ending at time zone 3 ( hour 8 postoperatively).
Complete response is defined as no PONV during 8 hours postoperative period. Incomplete response is
defined as developing of postoperative nausea only during 8 hours postoperative period. Failure of
prevention is defined as developing of PONV during 8 hours postoperative period.
Complete response occurred in 60 and 64% in Groups A and B respectively. Incomplete response
occurred in 12 and 4% in Groups A and B respectively. Failure of prevention occurred in 28 and 32%
in Groups A and B respectively.
There is no significant clinical difference between preoperative or postoperative Ondansetron
administration of the same dosage in both groups in prevention of postoperative nausea and vomiting.