Keywords : Miscarriage


Serum Progesterone &CA125 Levels as an Aid in the Prediction of Ectopic &Intrauterine Pregnancy

Maha M. Al-Bayati; Manal Madany A. Qader; Jinan Hadi Salma

Iraqi Postgraduate Medical Journal, 2015, Volume 14, Issue 1, Pages 7-13

ABSTRACT:
BACKGROUND :
Prompt diagnosis of ectopic pregnancy is a difficult dilemma, and reliable predictors for diagnosis and differentiation of ectopic pregnancy from early pregnancy miscarriage are needed.
OBJECTIVE:
To evaluate the diagnostic value of serum progesterone and CA-125 levels in ectopic pregnancy and early intra uterine miscarriage.
Study design: A prospective case control study
Setting: The study was carried out in the department of obstetrics and gynecology of AL-Yarmouk teaching hospital (Baghdad – Iraq) from February 2011 to February 2012
PATIENTS AND METHODS:
This study was carried out on sixty pregnant women in their first trimester. Twenty women diagnosed as unruptured ectopic pregnancy; treated by laparotomy ,twenty women diagnosed as inevitable miscarriage; treated by curettage and twenty women with healthy pregnancy of a comparable gestational age as control group; follow up of this group was done to ascertain uneventful pregnancy with no complications.
We compared the serum levels of progesterone and CA-125 in all groups at the time of presentation and 24h after surgical intervention in first and second groups.
RESULTS :
There was a significant decrease in mean post operative progesterone level in women with ectopic pregnancy and miscarriage groups with significant difference (P<0.0001). The study observed that the mean level of progesterone in women with ectopic group (6.76±3.63 ng/ml) was lower than that in miscarriage group (15.17±6.01 ng/ml) and control group (17.58±4.57 ng/ml) with significant difference (P<0.0001). This study also observed that the mean level of CA-125 in women with miscarriage group (117.07±94.30 U/ml) was higher than that in ectopic group (38.11±28.79 U/ml) and control group (30.51±16.10 U/ml) with statistically significant difference (P<0.0001).
There was a significant decrease in mean level of post operative CA-125 in women with ectopic pregnancy and miscarriage groups with significant difference (P<0.0003).
CONCLUSION:
Combined measurement of both serum progesterone and CA-125 can be sensitive predictors in diagnosis and differentiation of ectopic pregnancy from inevitable miscarriage and normal pregnancy.

Evaluation of Some Spontaneous Abortion-Causative Factors for Women in Baghdad Province A Serological and Histological Study

Samar A.AL-Gharrawi; Salim R.AL-Ubaidy; Bedir M.AL-Azawi

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 3, Pages 297-302

ABSTRACT:
BACKGROUND:
The spontaneous abortion is considered as one of the important clinical problems that may affects pregnant women during the 1st 20-22 weeks of pregnancy causing dangers to the mother and her fetus. The present study was designed to focus on some spontaneous abortion causes and intrauterine fetal death.
OBJECTIVE:
Study certain risk factors that may play a role in abortion such as serum level of , progesterone hormone , estradiol hormone , interlukine-6 and perform a histological study on placenta to identify any specific histop-
METHODS:
Seventy (70) Women were selected to represent the samples of spontaneous aborted women. The women were classified into two groups , the first represented aborted women during the first trimester of pregnancy (52) and the second were females in the second trimester of pregnancy (18) , in comparison with result of (20) normally delivered pregnancies. The samples (sera and placenta) were collected during the period from November 2008 to April 2009 in Baghdad.
RESULTS:
Significant decrease (p<0.01) in the level of progesterone and estradiol hormone was found in all aborted women at different stages of pregnancy compared with control. There was no significant difference (p>0.05) in level of IL-6 between aborted women and control. There was a correlation (positive) between progesterone with IL-6 in first and second trimester (p<0.05, p<0.01), respectively. And progesterone with estradiol (p<0.05) in second trimester. The histological study shows hydropic degeneration fibroids with hyalinization of fibrinosis changes.
CONCLUSION:
These results suggest an important role of progesterone, estradiol and IL-6 in spontaneous abortion women during first and second trimester. And apparition of the histological changes corresponding to the aborted women.