Keywords : KEY WORD


Levels of Interleukin-6 and Certain Antioxidants in Patients with Colorectal Cancer

Abdulnasser M. AL-Gebori

Iraqi Postgraduate Medical Journal, 2017, Volume 16, Issue 2, Pages 164-168

ABSTRACT:
BACKGROUND:
Colorectal cancer (CRC) is one of the most aggressive common tumors in humans. It is known that development and progression of tumors is associated with deviations in the human immune system.Interleukin-6 (IL-6) is a pro-inflammatory and anti-inflammatory cytokine that it is secreted by T cells and macrophages to stimulate immune response, during infection and after trauma. Antioxidants catalase (CAT), Glutathion (GSH), Ceruloplasmin (CP) and Malondialdehyde (MDA) are substances that when present at low concentrations compared to those of an oxidizable substrate significantly delays or inhibits oxidation of that substrate.
OBJECTIVE:
The main objective of this study is to determine the frequency of IL-6, CAT, GSH, CP and MDA in patients with CRC.
PATIENTS & METHODS:
This study included 40 healthy control donors (20 male and 20 female) and 60 patients with CRC (20 smokers male, 20 non smokers male and 20 non smokers female). They were obtained from the people attending the out Patient Clinic/ Baghdad Teaching Hospital in Medical City. Ages ranges were 40-60 years and matched by age and sex to healthy control donors with mean age 53.24 ± 2.32 years
RESULTS:
The mean values of IL-6 and CP in sera of patients (smoker and nonsmoker groups) with CRC were significantly increased as compared to healthy control donors (P<0.01) and the mean values of CAT, GSH and MDA in sera of patients (smoker and nonsmoker groups) with CRC were significantly decreased as compared to healthy control donors (P<0.01) and results analysis shows that the IL-6, CAT, GSH, CP and MDA of female with CRC are less than of a male.
CONCLUSION:
It is clear from this study that there is a relationship between the levels of IL-6, GSH, CAT, CP, and MDA concentrations and CRC patients and may be a good indicator to evaluate this disease.
r

The Effect of Age on Clinical Presentations of Patients with Atrial Fibrillation

Mahmood Riyadh Al-Haleem; Ali Jabbar Al-Ibrahemi; Taghreed Khazal Mohammed

Iraqi Postgraduate Medical Journal, 2017, Volume 16, Issue 2, Pages 169-175

ABSTRACT:
BACKGROUND:
Atrial fibrillation(AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function.
OBJECTIVE:
To demonstrate the effect of the age on clinical presentations of patients with atrial fibrillation.
METHODS:
This is a descriptive cross sectional study carried out in a tertiary cardiac center for 191 patients with atrial fibrillation who attended the selected hospital for any complaint.Their age was ranging from 18 years and above of both sexes.
RESULTS:
The more frequent age group for both sexes was between (40-65years). Palpitation was significant presentation in patient above 65 years and dyspnea and hypotention were more in patients below 40 years.The age is also had a significant effect on cardiomegaly on CXR, and on the echocardiographic findings of dilated LA, dilated LV, diastolic dysfunction and segmental wall abnormalities.
CONCLUSION:
The incidence of atrial fibrillation is age and gender related and age has an important effect on certain clinical presentations.

Serum MicroRNA-21 High Level Expression in Breast Cancer in Relation to Advance Stage

Adel Mosa AL-Rekabi; Shoroq Mohammed AL-Temimi

Iraqi Postgraduate Medical Journal, 2017, Volume 16, Issue 1, Pages 9-17

ABSTRACT:
BACKGROUND:
MiR-21 plays an important role in tumor formation and development , and it has been shown to be a key regulator of oncogenic processes and it may be a useful biomarker for breast cancer .
OBJECTIVE:
Estimation of miR-21 gene expression levels in both fresh tissues and serum of same breast cancer patients before and after operation by using stem-loop followed by Taq-Man Real Time PCR (RT-PCR) technique and correlate the miR-21 gene expression with stages of breast cancer and lymph node involvement.
MATERIAL AND METHODS:
Stem-loop RT-PCR was performed to identify the level of miR-21 gene expression in both fresh tissues and serum of same breast cancer patients before and after operation . The expression levels of miR-21 relative to mRNA of GAPDH were determined by using the livak method.
RESULTS:
Mean fold change of miR-21 was significantly higher in breast cancer than that of paracancerous tissues . Before operation ,the mean fold change of serum miR-21gene expression significantly statistical difference from healthy control ,the mean fold change of miR-21 in advance stage( III,IV) was significantly higher than that early stage (I,II) and mean fold change of miR‑21 in positive lymph node was higher than that of negative lymph node . After operation the mean fold change of serum miR-21gene expression was significantly higher than healthy control .A statistically significant difference was noted between advance stage with lymph node involvement and early stage with negative lymph node involvement .In contrast , the mean fold change of serum miR-21 was significantly lower from that before operation .
CONCLUSION:
Circulating miR-21 before and after operation can serve as a good biomarker for breast cancer detection and progression .

Post-Mortem Assessment of Glycemic Control in Sudden Diabetic Deaths Using Glycated Hemoglobin (HbA1c)

Saad kadhum Kareem

Iraqi Postgraduate Medical Journal, 2016, Volume 15, Issue 4, Pages 493-498

ABSTRACT:
BACKGROUND:
Post-mortem diagnosis of uncontrolled diabetes and its complications remains a common problem due to lack of unequivocal biochemical or histological proof of hyper or hypoglycaemia.In this study we evaluated glycated hemoglobin (HbA1c) as a post-mortem tool to identify uncontrolled diabetes.
OBJECTIVE:
To assess the use of glycated hemoglobin as an indicator for glycemic control in sudden diabetic deaths.
METHODS:
A cross-sectional study was carried out in the period from January 2015 to December 2015 on 47 sudden diabetic deaths and 22 natural non diabetic deaths at the Medico-Legal directorate in Baghdad. Information was collected from relatives, medical and police reports. A blood samples were drawn from the right ventricle of the heart of each decedent included in this study during autopsy. Blood was collected into sealed plastic tubes containing EDTA as anticoagulant and stored at 4ᵒc temperature. These samples were analyzed within a period of 48 hours. One micro liter sample of thoroughly mixed whole blood was placed into the glass capillary tube provided in the HbA1c reagent kit and analyzed with variant-Hb- testing system. Data were recorded in the SPSS for window 11.0.
RESULTS:
The study showed that the mean age group of diabetic sudden death was 50.28+-10.01 while 44.36+-16.11 year was non diabetic sudden death.
Male gender was the predominant in both groups (diabetic and non diabetic) 27.30%, 21.30% respectively.
%HbA1c was significantly deferred in diabetic and non diabetic group, when it was positive 100% in diabetic group, while it’s negative in non diabetic group (the cut off point is 6.5).
Type 2 diabetes was the predominant over type 1 with 59.60% and 40.40% respectively. The main system involved in sudden death in both study groups was the cardiovascular system accounting for 48.94% in diabetic group and 40.91% in control group, with the predominance of ischemic heart disease as the main cause of death in the system involved in both study groups accounting 40.43% for diabetic group and 22.73% for control group.
CONCLUSION:
HbA1c considered more reliable than post mortem glucose levels and provide guidance in the diagnosis of chronic diabetes mellitus in medico-legal autopsy cases.
c

Body Surface Area and Sheath Size as a Risk Factors for Vascular Complications After Coronary Angiography Via Femoral Approach

Salah Mahdy Majeed; Ali Mohammed Jawad; Haithem Ahmed Al-Rubaie; Zahraa Akram Thabit; Saad kadhum Kareem; Manal Madany A. Qader; Shatha Sami; Wisam Akram; Faten Shalal; Mustafa Nema; Mudher Al-Khairalla

Iraqi Postgraduate Medical Journal, 2016, Volume 15, Issue 4, Pages 481-485

ABSTRACT:
BACKGROUND:
Vascular complications have been recognized as an important factor in morbidity after diagnostic and percutaneous coronary interventions.
OBJECTIVE:
This study sought to evaluate vascular body mass index and sheath size as risk factors for vascular complications after diagnostic coronary angiography via femoral approach.
PATIENTS AND METHODS:
This historical prospective cohort study was carried out from February 2012 till January 2013, at the Iraqi Center for the Heart Disease. A total number of 2400 patients underwent 3600 procedures, diagnostic coronary angiography (2196) and PCI(1404) via their common femoral arteries.
Result: Body surface area > 2m2 is a statistically significant factor for vascular complications, and <1.6m2 is also an important statistically significant risk for vascular complications.
The results of the current study according to sheath size show:- during the diagnostic coronary angiograph procedures, sheath size 5F was the least(n=34), in which no reported vascular complications. Sheath size 6F (n = 1661) with (75) 4.5% complicated vs. (1586) 95.5% didn’t, sheath size 7F used among (501) patients, vascular complications developed in (171) 34.1% vs. (330) 65.9%. In comparison between the incidence of vascular complications among sheath sizes (6F, 7F) vs. 5F the P value < 0.001 for both.
During the PCI procedures, sheath size 6F was used among (140) patients, with vascular complications in one patient (0.7%). 7F used among (1219), with vascular complications in (115) 9.4%, and 8F used in (45) patients with vascular complications in (45) 100%. By using 6F as a referent, sheaths 7F&8F were statistical significant(p

Keywords

KEY WORDS: body surface area
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sheath size
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vascular complications.

The Association between Maternal Ghrelin Hormone Levels and Hyperemesis Gravidarum

Anwar Noori Al-Basam; AlaaAbdulateef Mohammad

Iraqi Postgraduate Medical Journal, 2016, Volume 15, Issue 3, Pages 358-364

ABSTRACT:
BACKGROUND:
Ghrelin hormone (Hunger hormone) is one of the appetite hormones that either secreted from adipose tissue (leptin, adiponectin and resistin), or mainly secreted from GI tract (ghrelin, obestatin, cholecystokinin, peptide YY and glucagon—like peptide –1). These hormones may be responsible for hyperemesis gravidarum.
OBJECTIVE:
To evaluate the role of ghrelin hormone in the etiopathogenesis of hyperemesis gravidarum
PATIENTS AND METHODS:
A case control study was performed in Gynecology and Obstetrics Department/ Baghdad teaching hospital(medical city complex) from the 1st of Sep. 2014 to the end of August 2015 including 100 women 50 women were the cases and 50 women were the control group.
RESULTS:
Mean age of cases was 24±8 years; prevalent age group was 20-29 years (48%).there was no significant difference in both groups regarding to the age, gestational age, gravidity and BMI between cases and controls (p>0.05). no significant differences were observed in TSH between cases and controls (p>0.05). But a significant association was observed between cases and low ghrelin level (p<0.001).
CONCLUSION:
there is a relation between the low level of ghrelin and hyperemesis gravidarum.

Epidermal Growth Factor Receptor (egfr) Immunohistochemical Expression in Gastric Carcinoma

Ali F.Hashim; Salim R.Al-Obaidie; Farah F.Hassan

Iraqi Postgraduate Medical Journal, 2016, Volume 15, Issue 3, Pages 379-384

ABSTRACT:
BACKGROUND :
Gastric cancer is the the fourth most common cancer and the second leading cause of cancer-related deaths. Gastric cancer is a major cause of cancer morbidity and mortality worldwide.
OBJECTIVE:
To estimate the immunohistochemical expression of epidermal growth factor receptor(EGFR) in the gastric cancer in relation to other parameters like grade and stage.
METHODS:
Formaline fixed ,paraffin-embedded blocks from 51 patients (29 male and 22 female) with gastric carcinoma were included in this study. Ten biopsies of normal gastric tissue were selected as a control group. Envision (DAKO) technique was applied to study the immunohistochem- ical expression of EGFR in paraffin embedded sections of gastric cancer.
RESULTS:
Positive immunohistochemical expression of EGFR was seen in 41.2% of cases as both membranous and cytoplasmic brown staining while there was negative staining in the normal control group (p<0.05). EGFR immunoexpression was correlated with the histological type( more in the intestinal variant than the diffuse type) (p<0.0.5).
CONCLUSION:
These findings provides further evidence for the role of EGFR in the tumorgenensis of gastric cancer. However, EGFR could not be well correlated with stage of tumor and hence may be poor prognostic parameters of the state of malignancy.

Spinal Intradural Meningioma and Neurofibroma: Personal Experience ,Clinical Presentation,Surgical Outcome

Yasir Mohammed HasanHamandi

Iraqi Postgraduate Medical Journal, 2016, Volume 15, Issue 1, Pages 28-34

ABSTRACT:
BACKGROUND:
Meningiomas and neurofibromas are the most common intraduralextramedullary tumors of of the spine
OBJECTIVE:
To study the incidence ,behavior and surgical outcome of intradural meningioma and neurofibroma .
METHODS:
This study was undertaken to analyze the 48 cases of intraduralmeningiomas and neurofibromas between January 1995 and December 2014 a total of 48 patients underwent surgical resection of a spinal meningioma and intraduralneurofibromas. 24 cases of meningiomaThere were 14 female and 10 male patients.24cases of neurofibroma 13 male & 11 female Age ranged from 20 to 70 years .The mean follow-up period was 50 months (range 1–116 months) including a complete neurological examination and postoperative MRI studies. The pre- and postoperative neurological state .
RESULTS:
Surgery was performed under standard microsurgical conditions with neurophysiological monitoring if needed. In meningioma, 11 the lesion was located in the thoracic region, in 6 in the cervical region, in 1 at the cervico-thoracic junction, in 1 at the thoraco-lumbar junction and in 5 in the lumbar region..Neurofibromas in24patient 13male and 11 female in10 the lesion was located in the thoracic region, in 8 in the cervical region, and in 5 in the lumbar region,1 in the thoraco-lumbar .Surgical resection was complete in 46 patients and subtotal in 2patients.At the last follow-up the neurological state was improved or unchanged in 46 and worse in 2 patients in menigiomas .
CONCLUSION:
resection of spinal meningiomas and neurofibromas can be performed with good functional outcome

Neuroblastoma: A Clinico-Epidemiological Study in AL-Khadhimyia Teaching Hospital

Iraqi Postgraduate Medical Journal, 2015, Volume 14, Issue 4, Pages 530-536

ABSTRACT:
BACKGROUND:
Neuroblastoma is the third most common childhood cancer, after leukemia and brain tumors, and is the most common solid extra cranial tumor in children. The term neuroblastoma is commonly used to refer to a spectrum of neuroblastic tumors (including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) that arise from primitive sympathetic ganglion cells.
OBJECTIVE:
The aim of this research is to study the epidemiological and clinical feature of
neuroblastoma in a group of Iraqi infants and children who were admitted to the pediatric ward of Al-Khadhimyia Teaching Hospital .
PATIENTS AND METHOD:
The study was done over a period of three months from 1st of Feb. 2010 to the end of Apr. 2010.In reviewing all files, 18 cases were collected from the Pediatric Hemato-Oncology Consultation Clinic in Al-Khadhimyia Teaching Hospital, they were diagnosed and treated consequently in the pediatric ward / hemato-oncology unit over a period of 9 years (2002-2010). Data regarding age, sex, residence, site of primary disease and clinical presentation were taken from the recording files in the pediatrics Hemato-Oncology Clinic. Methods used to diagnose our patients includes, fine needle aspiration of tumor mass, Bone marrow aspiration & biopsy of different sites. Chemotherapy was the main line of treatment.
RESULTS:
The total number of studied cases was eighteen cases. The median age was 15 months with male to female ratio of (0.63:1), 9 cases (50%) were below 1 year. Abdominal mass was the commonest site of tumor 12 cases (67%), weight loss was the most common symptom 18 cases (100%) followed by abdominal distention 14 cases(78%), abdominal mass represent the most common sign in 12 cases(67%). Stage IV was noticed in 9 cases (50%), 10 cases (56%) were a high risk group, 7 cases (38.8%) had bone marrow metastases, 6 cases (34%) finished treatment and survive, 4 cases( 22%) relapsed, 2 cases(11%) died.
CONCLUSION:
The majority of cases were recognized during the first two years of age .Female were involved more than male. The outcome of treated cases was good and accepted. Abdominal mass is the commonest site , weight loss is the commonest symptoms
.

Long Term Effect of Permenant Right Ventricular Pacing on Left Ventricular Systolic Function

Iraqi Postgraduate Medical Journal, 2015, Volume 14, Issue 4, Pages 487-491

ABSTRACT:
BACKGROUND:
Right ventricular apical pacing is associated with alterations of left ventricular contraction sequence and dilatation and may have a deleterious effect on left ventricular function.
OBJECTIVE:
The study investigates the correlation between left ventricular function and long term right ventricular pacing.
METHODS:
In this study, 80 patients with permanent right ventricular apical pacing (VDD and DDD) randomized to assess left ventricular systolic function particularly LVEF% .primary end point was LVEF% after 1 year of pacing.
RESULTS:
In this study, the mean LVEF% was reduced after 1year of right ventricular pacing from (67.47±2.94 to 55.89±8.41, p value 0.0001), with absolute reduction of about 12%.
Patients with LV systolic dysfunction (EF% less than or equal to 45%) which constitute 10 patients (12.5%) have mean baseline LVEF% (66.70±4.03 reduced to 37.50±6.38, P value 0.0001). Cumulative percentage of RV pacing and duration are predictors of LVEF% reduction.
CONCLUSION:
Conventional right ventricular apical pacing resulted in a significant reduction in the left ventricular ejection fraction, particularly in patients with high percentage of right ventricular pacing and should be suspected in any patients after long term pacing of right ventricular. Functional rather than topographic criterion should be considered for optimal pacing.

Prevalence and Risk Factors for Congenital Heart Anomalies Among Hospital Attendees in Mosul City

Eman Ghanim Sheet Al-Hyali

Iraqi Postgraduate Medical Journal, 2015, Volume 14, Issue 2, Pages 229-236

ABSTRACT:
BACKGROUND :
Congenital heart disease (CHD) define as abnormalities of heart structure that originate before birth, they are responsible for more deaths in the first year of life than any other birth defects.
OBJECTIVE:
To determine the prevalence of the identifiable CHDs and to identify risk factors that may predispose for its occurrence .
METHODS:
This is a case series hospital based study carried out in IB- IN- Al-Atheer teaching hospital of pediatric in Mosul city. during the period from April 2013 to April 2014 . 460 cases with CHD were compared with an equal number of controls selected from the general population and individually matched for age, sex, and family practitioner Information was obtained by Questionnaire sheets ,medical examination and investigations.
RESULT:
Out of 75320 attendants, 680 cases were referred to echocardiography unit where 460 cases of CHD were detected, the prevalence was (6.1/1000 patients). Atrial septal defect (42. %), ventricular septal defect was detected (30%) and Patent ductus arteriosus (9.3%) are the most common CHD detected. More than half of cases of CHD (86%) are detected at infancy with female- male ratio of 1.4:1 An association was found between family history, consanguinity and occurrence of CHD. Also an association was found between maternal risk factors such as mothers disease ,drug intake, obesity, smooking during pregnancy.
CONCLUSION:
CHD is a public health problem among infants and young children and there are many risk factors showed a significant effect on its occurrence such as positive family history, consanguinity and material risk factors during pregnancy So proper and timely counseling, regular antenatal care. folate supplementation especially during the most sensitive period of embryogenesis is essential to avoid congenital heart malformation

Impact of Weight Loss Achieved Through Gastric Sleeve Surgery with Circulating Level of Ghrelin Hormone in Obese Subjects

Zainab A. Razak A. Ghani; Ramiz Sami Mukhtar; MuayadAbassFadhel; Kisma M. Turki

Iraqi Postgraduate Medical Journal, 2015, Volume 14, Issue 2, Pages 216-221

ABSTRACT:
BACK GROUND:
The epidemic of obesity is a major health problem in the developed world with a great influence on morbidity and mortality.
OBJECTIVE:
To evaluate serum ghrelin levels achieved through LSG and on insulin resistance and the serial changes of insulin concentration in obese patients following gastric sleeve.
SUBJECTS AND METHODS:
Twenty four patients underwent LSG with 25 controls were selected. Body mass index (BMI), waist circumference (WC), lipid profile, fasting blood sugar (FBS), glycated hemoglobin (HbA1c), fasting insulin, QUICKI and ghrelin hormone concentrations were measured for controls and patients prior LSG, then one month and three months post-surgery.
RESULTS:
A significant decline was noticed in BMI, WC, TC, TG, LDL-cholesterol, fasting insulin, and ghrelin, with significant increase in QUICKI in patients undergone LSG with significant differences in all studied parameters between patients and controls. A negative correlation was noticed between ghrelin and BMI in patients before sleeve gastrectomy.
CONCLUSION:
Ghrelin is a hormone closely linked with obesity taking into account the marked loss in appetite in the period after laparoscopic sleeve gastrectomy.

Value of Fine Needle Aspiration Cytology Under Ultra-Sound Guided Biopsy in the Diagnosis of Prostatic Cancer

Usama S.Al-Nasiri; Adil H Hamoodi; Raghib J Hameed

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 3, Pages 384-389

ABSTRACT:
BACKGROUND:
The detection of carcinoma of prostate (CaP )by trans rectal ultrasound (TRUS) depends on the feature produced by the new growth , which leads to changes in the glandular —stromal architecture, appears as Changes in the echogenicity of the prostatic lesion. The fine needle can be guided to the area of suspicion and cytology is done.
OBJECTIVE:
This prospective study was conducted to demonstrate the usefulness of the fine needle aspiration cytology (FNAC) under transrectal ultrasound (TRUS) guidance in detection of carcinoma of the prostate (CaP).
METHOD AND PATIENTS:
Fifty male patients aged between (46 - 86) years, were chosen selectively, all with voiding symptoms & suspicion of CaP from an elevated prostate specific antigen (PSA) above the level of 4 ngml in all patients. Thirty patients had abnormal finding on digital rectal examination (DRE), thirty three patients had TRUS abnormal findings. This procedure was carried out in out – patient basis. The cytological results were compared with the tissue diagnoses obtained by surgical interventions.
RESULTS:
The cytological results revealed 24 case of malignancy & benign in the rest 26 case (23 case of BPH & 3cases of prostatitis).Malignancy was correctly diagnosed by using cytology in 24 out of 28 case confirmed by histopathology as CaP. One case was considered initially as false positive, the cytological result consistent with adenocarcinoma but the histopathology failed to prove it.
The statistical analysis revealed that the sensitivity, specificity and accuracy were 85%. 100% & 92% respectively.
CONCLUSION:
We conclude that FNAC under TRUS guide can be considered as an initial safe cost effective & reliable method for diagnosing of Prostate cancer.

Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in Ibn Alnafees Hospital, Baghdad

Majid Abdul Muhsin Falih; Alaa AbdulHussein Allawi; Raed Sabri Al Abboodi

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 3, Pages 310-312

ABSTRACT:
BACKGROUD:
Primary percutaneous coronary intervention (PCI) provides outcomes superior to fibrinolytic therapy in acute myocardial infarction (AMI), but no registry or study in Iraq has demonstrated its use in hospital.
OBJECTIVE:
To evaluate using of primary PCI for acute MI in Ibn Alnafees hospital –Baghdad.
METHODS:
Patients between 2010 and march 2013 having symptom onset within 12 hours and either ST-segment elevation of - 1 mm in - 2 contiguous leads or presumed new left bundle branch block (LBBB) in electrocardiogram (ECG) who were treated with primary PCI were included in this study. Two patient had cardiogenic shock treated within 16 hours.
RESULTS:
A total of 76 patient included in this study having primary PCI for acute MI. successful result reported in 71 of cases, while death reported in 2 cases, slow flow in 2 cases, no re flow in one case and stent thrombus formation in one case. No need for urgent or elective CABG.
CONCLUSION:
Primary PCI for patients with AMI having ST-elevation or new LBBB is a safe and effective strategy

Outcome of Induction Therapy in Adult Patients with Acute Myeloid Leukemia

Alaadin Sahham Naji

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 3, Pages 313-319

ABSTRACT:
BACKGROUND:
Treatment of patients with newly diagnosed acute myeloid leukemia (AML) has improved during the past decades due to the intensification of induction and post remission chemotherapies and due to the incorporation of autologous and allogeneic transplantation procedures. Untreated acute leukemia is a uniformly fatal disease with a median survival time shorter than 3 months.
OBJECTIVE:
To evaluate the outcome of induction and complications post induction in adult patients with Acute Myeloid Leukemia(AML) in Baghdad Teaching Hospital
PATIENTS AND METHODS:
A total of 47 patients diagnosed as de novo AML who had been admitted within twelve months from January till December 2012 in hematology unit of Baghdad Teaching Hospital were included. Treatment of the 47 eligible patients for remission induction with standard intensive treatment course consisted of the combination with standard-dose cytosine arabinoside 100 mg/m2/d continuous infusion on days 1-7, with of doxorubicin in a dose of 30mg/m2 over half an hour infusion on day 1-3.Response to therapy was assessed for complete remission or persistence of leukemic cell post induction. Pattern and severity of infections and their relationship with granulocytopenia. were analyzed.
RESULTS:
The patients had a mean age of of 36.7 years ranged from 14 to 72 years. Performance status in 15 patients was 0 or I while the majority (43) patients was with PS of II-IV at diagnosis according to WHO/ECOG performance status scale. Duration between symptoms of AML prior diagnosis till suspicion of a diagnosis of AML at a referring hospital and confirmation of the diagnosis at our institute have been assessed with( mean +SD) duration 32±22.1days.
of the 47 patients 22(47%) achieved complete remission post first induction (CR1)and further 5(11%) patients have CR2(after second remission) and 20(42%) was refractory to treatment. Focus of infection during marrow hypoplasia have been identified in 26(59%) patients.
CONCLUSION:
Based on the current data ,the remission rate was nearly comparable to the results with other reports . Intensification of anthracyclins and identification of cytogenetic and other independent prognostic relevance are needed to obtain better results.

The Predictive Value of Intima-Media Thickness of the Common Carotid Artery in the Prevention of Stroke

Riyadh S. Abultiman; Abdulhameed A. Majeed Al-kassir; Namir M. Taher Abdullah

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 1, Pages 75-80

ABSTRACT:
BACKGROUND:
Non invasive measurement of intime-media thickness(IMT) of the common carotid artery by high resolution ultrasonography and its importance in stroke patient.
OBJECTIVE:
The study was designed to study this relation in our locality.
PATIENTS AND METHODS:
Thirty patients with ischemic stroke that were admitted in the medical department of Al Yarmook teaching hospital were tested by the aid of echocardiography department to measure intima-media thickness of the common carotid artery and they were compared with 20 persons(matching age and sex) without history of stroke or transient ischemic attack.
RESULTS:
The mean of IMT of common carotid artery in stroke pateints was 1.24mm while in control group the mean was 0.765 mm.
CONCLUSION:
There is a significant relation between the increased IMT of common carotid artery and stroke.

Effect of Hypertension on Aortic Root Size and Prevalence of Aortic Regurgitation

Ghassan Abbod Ahmed; Amal Noori Al; Marayati; Basil Najeeb; Asaad Abdullah Abbas; Talib Hashim Salim; Basil Najeeb Saeed; Riyadh S. Abultiman; Abdulhameed A. Majeed Al-kassir; Namir M. Taher Abdullah; Zainab Abdul Razak AL-SharifiA; Halla Ghazi Mahmood; Amjad Daoud Niazi; Hassan Sarhan Haider; Rafal Rajab Hasan; Alaa Hussein Altaee; Raghad Hannon Shinenalsudani; Iyad Abbas Salman; Saba J. AL-Wardi; Khudir Z. Mayouf; Faiq. I. Gorial; Warda S. Lasso; Mohanned A. Al-Falahi; Mohammad Saeed; Sinan Adnan; Islam Ghanem Mahmood; Ali A. Muttalib Mohammed; Ammar Hadi Khammas; Mohammed Radef Dawood; Yaseen Adeeb Sakran; Azad Mohammed Abdullah; Bassam Musa Sadik Al-Musawi; Waleed Mustafa Hussen; Osama Elhassani; Muhanad Fadhil

Iraqi Postgraduate Medical Journal, 2014, Volume 13, Issue 1, Pages 61-69

ABSTRACT:
BACKGROUND:
Although early reports suggested that hypertension predisposed to aortic root enlargement and consequent aortic regurgitation, more recent pathological and M-mode echocardiographic studies have not found an association between hypertension and aortic root enlargement when age is considered.
OBJECTIVE:
The aim of this study is to asses the effect of hypertension on aortic root size and to estimate the prevalence of aortic regurgitation.
METHODS:
measurement of two-dimensional echocardiographic diameters of the aortic root at four locations and compared findings with resting blood pressures and measures of body BMI in 110 normotensive and 110 hypertensive men and women matched for age and sex.Colour and continuous wave Doppler study are used to diagnose and assess severity of aortic regurgitation.
RESULTS:
Aortic diameters at the anulus (2.40±0.29 versus 2.33±0.24 cm, P=.06) and sinuses (3.45±0.43 versus 3.35±0.35cm, P=.08) were marginally higher, whereas diameters at the supra-aortic ridge (2.93±0.39versus 2.73±0.33cm, P

Keywords

such a difference in this population of
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asymptomatic hypertensive individuals.