Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND :
Midazolam is one of benzodiazepines. It is most lipid soluble as a result has a rapid onset and short duration of action, used in anesthesia for sedation or intravenous induction according to the dose used.
OBJECTIVE:
Is to notice if there is an effect of midazolam on heart rate in pediatric patients with using ketamine as induction agent under general anesthesia.
PATIENTS AND METHODS:
60 peadiatric patients undergoing surgery randomly allocated in 2 groups(A and B). Aneasthesia was standardized for all patients (except addition of Midazolam in sedative dose (0.03 mg/kg) i.v. preinduction to group( B). Heart rate measured preoperatively as abaseline and 5 and 15 minutes after induction.
RESULTS:
Adding midazolam associated with a reduction in HR by an average of 10 beats/min 5 and 15 minutes after induction of anaesthesia. This effect failed to reach the level of statistical significance although it was clinically significant.
CONCLUSION:
Midazolam have well known sedative effect but have no significant effect on heart rate in paediatric patients.