Association of Serum Levels of 25 Hydroxyvitamin D and Type 2 Diabetes Mellitus: Age and Gender Dependent Study
Iraqi Postgraduate Medical Journal,
2017, Volume 16, Issue 2, Pages 138-143
Vitamin D deficiency has been found to have an inverse relationship with the occurrence of diabetes mellitus (DM). The aims of this study were to investigate the serum levels of vitamin D in type 2 DM and to correlates the obtained values with their age and gender.
SUBJECTS AND METHODS:
This case-control study was carried out at Al-Ramadi General Teaching Hospital, and the National Diabetes Center for Treatment and Research at Al- Mustansiriya University, Iraq, during the period from December 2014 to November 2015. It involved, 80 patients with type 2 DM, and 60 healthy subjects. Investigations included serum measurement of 25 Hydroxyvitamin D (25OHD), fasting glucose, Insulin, glycated hemoglobin (HbA1c) in all patients and controls using ELISA technique.
The median concentration of serum 25 OHD of patients with type 2 DM (15.70 ng/ ml) were significantly lower than that of healthy controls (20.27 ng/ ml, P= 0.001). The rate of vitamin D deficiency (VDD) was significantly higher in type 2(82.5%) diabetic patients than in healthy controls (48.3%, P=0.001). Type 2 diabetic patients with age of 60 years and above and female had the highest VDD compared to others, type 2 diabetic patients with age of ≥ 60 years increased the risk of having VDD by 9.8 times compared to those with age group <18 years, but still insignificant (P =0.07).
The results revealed significant deficiency of serum vitamin D in diabetic patients type 2. Supplementation of vitamin D may improve the control of this syndrome or even delay its incidence and complication.
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