A Study of Adiponectin/Leptin Ratio in Adult Males with Metabolic Syndrome
Iraqi Postgraduate Medical Journal,
2018, Volume 17, Issue 4, Pages 355-359
Metabolic syndrome is a disorder of energy utilization and storage. It is a multi-component disease
brought on by a combination of life style and environmental factors, with some populations
exhibiting a genetic predisposition and type 2 diabetes. It is marked by abdominal obesity, elevated
levels of triglyceride, low levels of HDL (good) cholesterol, high blood pressure and high blood
sugar levels. Metabolic syndrome is a significant risk factor for the development of both type 2
diabetes and heart disease, also associated with fatty liver, and polycystic ovary syndrome.
Recently two adipocytokines secreted from visceral adipose tissue leptin and adiponectin, have
been recognized as key regulators of various metabolic disorder.
The objective of this study was to use the adiponectin to leptin ratio as a parameter and a lab index
to predict metabolic syndrome across adult males.
A total of 82 adult males with mean age of (38.47 + 9.27) were included in the study. Fifty eight
(58) adult males were the metabolic syndrome group depending on the presence of any 3 out of 5
of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria
which include the following: (central obesity ≥ 102cm, triglyceride ≥150 mg/dl, HDL-Cholesterol
˂40 mg/dl, blood pressure ≥ 130/85 mmHg and fasting serum glucose ≥100 mg/dl) as compared to
twenty four (24) healthy adult males as the control group.
The findings showed that adiponectin/ Leptin ratio is significantly lower in metabolic syndrome
adult males as compared to healthy adult males.
In conclusion data indicate that adiponectin/leptin ratio is a plausible index for detecting the
presence of metabolic syndrome in adult males.
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