Association of Insulin Resistance with Overactive Bladder Syndrome in Female Patients
Iraqi Postgraduate Medical Journal,
2021, Volume 20, Issue 3, Pages 221-226
Overactive bladder Syndrome refers to a group of lower urinary tract symptoms related to the storage of urine in the bladder. Normally the bladder fills and stores urine without discomfort or leakage. The sensation of bladder fullness gradually increases until the need to void comes to conscious awareness. In those who have overactive bladder, however, the sensation to void is altered (and generally delayed) to the extent that involuntary urination may occur. current evidence suggests that it may be associated with insulin resistance .
AIM OF STUDY:
We aimed to investigate the association of insulin resistance with overactive bladder in female patients.
PATIENT AND METHODS :
We prospectively conducted the study in our urogynecological department. Female patients aged between 30 and 76 years with or without overactive bladder syndrome OABS symptoms were enrolled. Fifty patients with OABS and fifty age-matched controls without OABS were included in the study. Fasting serum insulin and fasting blood sugar were measured. Insulin resistance value was obtained via the homeostasis model assessment of insulin resistance (HOMA-IR) calculator.
There was no significant difference in the age, and mode of delivery between women with or without overactive bladder (OAB), while BMI and parity number were significantly higher in OABS women. FBS, fasting insulin (11.2 vs. 7.9 𝛍U/ml) , HOMA-IR value (2.62 vs. 1.77) and insulin resistance (IR) was significantly higher in OABS women, in which 50% had IR while 12% had IR in women with or without OABS. In multivariate analysis insulin resistance (IR≥2.5) , age, increased BMI, higher parity, and CS history were independent predictors of overactive bladder.
- insulin resistance is associated with overactive bladder syndrome, and about half of the women with overactive bladder presented with insulin resistance
- Hyperinsulinemia is strongly associated with overactive bladder
- Obesity is an independent predictor of overactive bladder
- HOMA-IR equation can be used as diagnostic methods that assist in confirmation of overactive bladder diagnosis by 20 – 25% additional increase in the index of suspicion.
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