Evidence of Correlation between Some Auto Antibodies with Complement Component in Lupus Nephritis
Iraqi Postgraduate Medical Journal,
2007, Volume 6, Issue 1, Pages 54-57
lupus nephritis is a fatal complication of systemic lupus erythematosus (SLE), the serological hallmark of SLE is the presence of circulating autoantibodies directed against a wide variety of nuclear, cytoplasmic and plasma membrane antigens among which are anticardiolipin (ACL),anti-B2glycoprotein and anti-C1q antibodies, together with the consumption of complement component (C3 &C4) by immune complex mediated reaction.
AIM OF STUDY:
To shed light on the relations among these autoantibodies and with complement component in lupus nephritis patients.
Tthe study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritia and 25 healthy controls.
Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP, anti-C1q, while single radial immundiffusion plates used for the estimation of C3& C4.
RESULTS AND CONCLUSION:
Anticardiolipin antibodies correlated significantly with anti-B2GP IgG & IgM (P<0.05), anti-C1q antibodies (P
Uropathogenic Escherichia coli
Liquefied propane gas
intestinal parasitic infections
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