Human Leukocyte Antigen-DP in Acute Nonlymphocytic and Acute Lymphoblastic Leukemia
Iraqi Postgraduate Medical Journal,
2006, Volume 5, Issue 3, Pages 285-288
Acute leukemias are characterized by the elonogenic proliferation of hematopoietic progenitor cells arrested in maturation .Clinical manifestations are related to the infiltration of the bone marrow and other tissues by the leukemic blasts.
Peripheral blood mononuclear cell (PBMC) from leukemic patients (29)(ANLL),(36)(ALL) and from normal donors(55)were typed for Human leukocyte antigen-DP specificities using microlymphocytotoxicity assay.
Results showed frequencies of (DPw) alleles in (ANLL) patients were not significantly different from controls ,exept that in DPw1 was absent .In contrast ,in ALL,frequencies of DPw2 and DPw5 were significantly increased (p< 0.05,relative risk (RR)= 1.95 and p<0.01,RR=4.27,respectively .
These results ,demonstrate both positive and negative associations between major histocompatibility complex (MHC) gene products which are in only very weak linkage with the rest of HLA ,and (ALL,ANLL) patients.The HLD-DP region could thus contain long sought –after genes influencing susceptibility and resistance to leukemogenesis.
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