Effectiveness of Non Steroidal Anti Inflamatery Drug "Diclofenac Sodium" in Treatment of Nocturia in Benign Prostatic Hyperplasia Patien
Iraqi Postgraduate Medical Journal,
2011, Volume 10, Issue 3, Pages 311-316
We explored the effectiveness of enteric coated diclofenac sodiumfor patients with benign prostatic hyperplasia (BPH) complaining of nocturia. A total of 30 BPH patients aged 50-75 years were enrolled in the study. They each took a single 50-mg tablet of diclofenac sodium prior to sleeping at night for 14 days in addition to their BPH treatments In the questionnaire ,21 of 30 patients (70%) felt more satisfaction than previous treatments.
In this study, we attempted to investigate the role of enteric coated diclofenac sodium (voltaren) in the therapeutic management of BPH patients with nocturia.
Thirty patient with BPH ( 63.6± 6.56 years old) more than two episodes of nocturia per night were involved. These patients had received standard drug therapy. Although these patients had received standard drug therapy for more than half a year, they had still three or more episodes of nocturia. The patients took a single dose of 50 mg of diclofenac sodium enteric coated at night prior to sleep. Before and 2 week after the initiation of this therapy, the effects of this treatment were assessed by frequency volume chart and a questionnaire.
In the questionnaire ,21 of 30 patients (70%) felt more satisfaction than previous treatments. Patients were grouped into a diclofenac sodium-effective (n = 23) and ineffective groups (n = 7) based on the results of the frequency-volume chart. In the effective group, interestingly, night-time urine volume showed significant reduction (P < 0.001). On the other hand, the average single voided volume at night showed no significant change. There was a statistically significant difference in the night-time urine volume after treatment between groups (P < 0.05). In frequency volume chart, total void per day, total void per night, total urine volume per day, total night urine volume per day and single voided volume in the night before and after this treatment were 9.9±0.56and 10.1±0.69per day, 3.9±0.87 and 2.3±1.1 per night, 1500.2±106.9 and1508.7±107.3 mL per day, 580.2±136.9 and 350.4±169.3 mL per night, and 150±7.2 and 150.4±7.05mL, respectively, in a diclofenac sodium-effective group.
Diclofenac sodium can be effective and useful for BPH patients with nocturia
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