The Effect of Obesity on Serum Leptin and Lipid Profile
Iraqi Postgraduate Medical Journal,
2009, Volume 8, Issue 1, Pages 27-32
Obesity has become a leading health concern; this condition is a chronic, complex, multifactorial disease in which a person's weight is ≥ 20% of the ideal weight for a given height.
To measure serum leptin level and lipid profiles levels in Iraqi obese individuals comparing the results with matching non obese subjects.
The study was carried on 30 individuals divided into two groups:
1. Obese subjects group (n=20).
2. Non-obese subjects group (n=10).
For all subjects studied measurements of fasting serum leptin and lipid profile have been done.
Our study showed that mean serum leptin level was significantly higher in obese than non-obese individuals (P<0.001). In addition serum leptin correlates positively and strongly with body mass index (BMI) ( r=0.765,P<0.01). Serum leptin also correlates positively with both triglyceride (TC)(r =0.394, P<0.05) and low density lipoprotein (LDL) (r=0.366,P<0.05) but correlates negatively with high density lipoprotein (HDL)(r=-0.408,P<0.05).
circulating leptin levels appear to be one of the best biological markers of obesity and hyperleptinemia is closely associated with several risk factors related to obesity syndrome.
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