Serum Enzyme Activities in Human Thyroid Diseases
Iraqi Postgraduate Medical Journal,
2010, Volume 9, Issue 4, Pages 549-554
The study enrolled a total of 76 patients with thyroid gland diseases, hyperthyroidism and
hypothyroidism. The activities of the enzyme amylase, gamma glutamyltransferase and alkaline
phosphatase were evaluated in these diseases state and were compared with normal healthy thyroid
gland. The specimens were obtained from different hospitals in Baghdad and from routine clinical
Diagnosis of patients with thyroid gland diseases hyper and hypothyroidism by evaluation of
enzymes activity of amylase, GGT and ALP.
Two groups of patients were used: The first consists of 38 patients with hyperthyroidism, the
second consists of also 38 are patients with hypothyroidism. Twenty five of each group was
investigated for amylase, GGT, ALP and were compared with third group of 25 normal healthy
thyroid gland. The remaining 13 out of 38 patients of each group were tested for enzymes,
amylase, GGT, ALP, GOT, GPT and evaluate the hormones, they were compared with third group
of 10 normal healthy thyroid gland.
There was a highly significant increase and decrease in the activity of amylase, GGT and ALP in
hyper and hypothyroidism patients (P<0.001) when compared with third group normal.
Diagnosis of patients with thyroid gland diseases can be confirmed by enzymes investigation in
blood serum and hormonal assay
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