In vitro Resistance to Cephalosporins in Women with Bacterial Urinary Tract Infections
Iraqi Postgraduate Medical Journal,
2012, Volume 11, Issue 3, Pages 321-325
Urinary tract infections are the most frequent nosocomial and community-acquired infections. Cephalosporins have a role in treating urinary tract infections, but are not recommended for empiric therapy because of the relatively high rates of resistance and low efficacy. Effective management of urinary tract infections has been hampered by the fact that many strains have developed resistance to several antimicrobial agents.
A. To demonstrate the common local bacterial pathogens and, B. To test the in-vitro the susceptibility to cephalosporinsin women with urinary tract infections.
PATIENTS AND METHODS:
One hundred and twenty women from the outpatient department ofAlbatoolMaternity Teaching Hospital from the coauthor's private clinic with signs and symptoms of uncomplicated acute urinary tract infections with no previous history of antibiotic intake were included in the study. Culture and sensitivity tests to cephalosporins and other antibiotics were done to all of them.
Six types of bacterial species were isolated from the urine samples. E. coli was isolated from 49 cases (40.83%), Klebsiella was found to be the second most common bacteria isolated in 31cases (25.83%).About one third of E. coli, Klebsiella, Proteus and Citrobacterwere resistant to cephalosporins.E. coli and Klebsiella resist most cephalosporins.
Many types of bacteria cause urinary tract infection, most of these bacteria resist cephalosporins. Cephalosporins should not be used as first line therapy and when used have to be preceded by culture and sensitivity testing.
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