The Effect of Aspirin on Histology of Placenta
Iraqi Postgraduate Medical Journal,
2014, Volume 13, Issue 3, Pages 434-441
Preeclampsia (PE )is a potentially life-threatening hypertensive disorder affecting_ 2-7% of all pregnancies , It is a leading cause of maternal mortality ,and associated with high perinatal mortality and morbidity, including intrauterine growth restriction (IUGR) and prematurity. A daily low dose of aspirin (60-80 mg /day) may use for prevention and treatment of PE and fetal growth retardation in pregnant women at risk.
To assess the influence of aspirin therapy on the histology of placenta from mothers with PE and to correlate the findings with those from pre -eclamptic mothers but not using aspirin during their pregnancy and with placenta from normal Pregnancies .
This study was carried out on one hundred twenty –pregnant women, thirty five with uncomplicated pregnancy and eighty five mothers with PE , fifty of these hypertensive women on aspirin therapy since first trimester.
It was found that mothers with pre- eclampsia either take aspirin or not had relatively smaller, irregular placentae. Histological features of vascular insufficiency like thrombosis, cytotrophoblastic cellular proliferation, fibrin plaque formation etc. were present in more or less similar amount in both groups of hypertensive placentae. Babies of such mothers were mostly
small for date.
Despite the little improvement in outcomes of the aspirin treated pregnancy, , histologic evidence of placental pathology persisted in the majority of women with PE. so aspirin therapy is not effective in preventing and treatment PE
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